In vitro and in vivo chemotherapeutic activity of rifabutin (LM 427) on Mycobacterium avium-intracellulare complex.
نویسندگان
چکیده
منابع مشابه
Rifabutin therapy for disseminated Mycobacterium avium complex infection.
Although numerous antimicrobial agents have been used to treat disseminated Mycobacterium avium complex (MAC) infection, the optimal therapy for this disease is unknown. One potentially effective agent is rifabutin, which has demonstrated activity against MAC both in vitro and in animal models of infection. In clinical trials, cultures of blood from 46% to 92% of patients become sterile after t...
متن کاملProspects for development of new antimycobacterial drugs, with special reference to a new benzoxazinorifamycin, KRM-1648.
In this article, I have thoroughly reviewed the status of development of new antimycobacterial drugs, in particular, rifamycin derivatives (rifabutin, rifapentine, and a new benzoxazinorifamycin, KRM-1648), fluoroquinolones (ciprofloxacin, ofloxacin, sparfloxacin, levofloxacin, gatifloxacin, sitafloxacin, moxifloxacin, and others), new macrolides (clarithromycin, azithromycin, roxithromycin), a...
متن کاملIn vitro and ex vivo activities of antimicrobial agents used in combination with clarithromycin, with or without amikacin, against Mycobacterium avium.
MICs of clarithromycin, amikacin, isoniazid, rifabutin, ciprofloxacin, sparfloxacin, ethambutol, and clofazimine were determined for six isolates of Mycobacterium avium complex (MAC) from AIDS patients both by the radiometric method and by an ex vivo model of infection in human macrophages. The median MICs in macrophages were similar or slightly lower than values found in broth, except for amik...
متن کاملMycobacterium-avium-intracellulare complex immune reconstitution inflammatory syndrome in HIV/AIDS presenting as osteomyelitis.
We report a case of osteomyelitis due to Mycobacterium avium-intracellulare complex (MAC) in an AIDS patient shortly after the initiation of antiretroviral therapy with subsequent immune reconstitution inflammatory syndrome (IRIS). He improved after surgical debridement and treatment with clarithromycin, ethambutol, rifabutin, and low-dose corticosteroids. Antiretroviral therapy was not interru...
متن کاملUveitis associated with rifabutin and macrolide therapy for Mycobacterium avium intracellulare infection in AIDS patients.
OBJECTIVE Uveitis has been increasingly recognised as a side effect of rifabutin regimens in the prophylaxis and treatment of Mycobacterium avium intracellulare (MAI) infection. This study describes the clinical features and analyses the factors associated with rifabutin induced uveitis. DESIGN Retrospective observational study. SETTING Tertiary care institution, The Royal Hospitals NHS Tru...
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عنوان ژورنال:
- Bulletin of the Chest Disease Research Institute, Kyoto University
دوره 20 1-2 شماره
صفحات -
تاریخ انتشار 1987